OPTICAL SENSOR AND METHOD

专利摘要:
fluorometer with multiple detection channels. an optical sensor may have multiple sensing channels to detect different characteristics of a fluid. for example, an optical sensor used in industrial cleaning and sanitizing applications may have multiple detection channels to detect when a system is cleaned and properly sanitized. in one example, an optical sensor includes an optical emitter that directs light into a fluid, a first optical detector that detects light transmitted through the fluid, a second optical detector that detects light scattered by the fluid, and a third optical detector that detects emissions. fluorescent emitted by the fluid. the optical emitter and optical detectors can be positioned around the optical analysis area. depending on the application, the optical emitter can be positioned to direct light adjacent to a wall of the optical analysis area rather than a center of the optical analysis area, which can increase signal strength in the detection channels.
公开号:BR112015021347B1
申请号:R112015021347-2
申请日:2014-03-06
公开日:2021-09-08
发明作者:Eugene Tokhtuev；Christopher J. Owen；Anatoly Skirda；Viktor Slobodyan；Paul Simon Schilling；William M. Christensen
申请人:Ecolab Usa Inc；
IPC主号:

专利说明:

TECHNICAL FIELD
[001] This description refers to optical measuring device and, more particularly, to fluorometers to monitor the concentration of one or more substances in a sample. BACKGROUND
[002] In cleaning and antimicrobial operations, commercial users (eg restaurants, hotels, food and beverage factories, supermarkets, etc.) rely on the concentration of a cleaning and antimicrobial product to make the product work effectively . The failure of a cleaning and antimicrobial product to function effectively (eg, due to concentration issues) can cause a commercial user to perceive the product as of inferior quality. End consumers may also perceive the commercial provider of such products as providing inferior services. In addition, commercial users can be investigated and/or sanctioned by government regulatory and health agencies. Consequently, there is a need for a system that can monitor the characteristics of fluid solutions, for example, to determine whether the concentration of a product is within a specified concentration range. The same may be true for other applications such as water care, pest control, bottling and beverage operations, oil and gas processing and refining operations, and the like.
[003] A method of monitoring the concentration of a product relies on monitoring the product fluorescence that occurs when the sample (and the product within the sample) is exposed to a predetermined wavelength of light. For example, compounds within the product or a fluorescent label added to the product may fluoresce when exposed to certain wavelengths of light. The product concentration can then be determined using a fluorometer that measures the fluorescence of the compounds and calculates the chemical concentration based on the measured fluorescence.
[004] Fluorometric spectroscopy refers to the detection of fluorescent light emitted by a sample of interest. It involves using a Luiz beam, usually ultraviolet (UV) light, which excites electrons in molecules of certain compounds in the sample and causes them to emit light (ie, “fluoresce”). There are several types of fluorometers for measuring emitted fluorescence. Fluorometers generally have a radiant excitation energy source and a detector with a signal processor and a readout device. SUMMARY
[005] In general, this description is directed to fluorometric devices, systems, and techniques for monitoring fluid samples. A fluorometer according to the description may include an optical emitter and multiple optical detectors to monitor different characteristics of the fluid sample. For example, a fluorometer can include an optical emitter that detects light passing from the optical emitter and through the fluid sample to determine the concentration of a non-fluorescent species in the fluid. The fluorometer may further include another optical detector that detects fluorescent emissions from the fluid sample to determine the concentration of a fluorescent species in the fluid. By configuring the fluorometer with multiple optical detectors, the fluorometer can monitor different characteristics of a fluid under analysis. For example, when used to monitor water samples from an industrial cleaning and sanitizing operation, the fluorometer can determine if the wash water is clean (ie, sufficiently devoid of product being washed) and contains a sufficient amount of sanitizer.
[006] Although the design of the fluorometer may vary, in some applications the fluorometer includes an optical emitter that is offset relative to an optical analysis area through which the fluid flows. The optical emitter can be moved so that light emitted from the optical emitter is directed adjacent to a wall of the optical analysis area rather than at a center of the optical analysis area. Such an arrangement can help to minimize the amount of light emitted by the optical emitter that is reflected, for example, due to turbidity of fluid or wall surfaces in the optical analysis area. In turn, this configuration can increase the signal strength provided by an optical detector detecting light from the optical analysis area.
[007] In one example, an optical sensor is described that includes an optical emitter, a first optical detector, a second optical detector, and a third optical detector. The optical emitter is configured to direct light onto a fluid sample. The first optical detector is configured to detect light emitted by the optical emitter and transmitted through the fluid sample. The second optical detector is configured to detect light emitted by the optical emitter and diffused by the fluid sample. The third optical detector is configured to detect fluorescent emissions emitted by the fluid sample in response to light emitted by the optical emitter. According to the example, the optical sensor also includes an optical emission filter positioned between the optical emitter and the fluid sample, a first optical detection filter positioned between the first optical detector and the fluid sample, a second detection filter optical detector positioned between the second optical detector and the fluid sample, and a third optical detection filter positioned between the third optical detector and the fluid sample. The example further specifies that the optical emission filter, the first optical detection filter, and the second optical detection filter are configured to filter the same wavelengths of light so that substantially any light detected by the first optical detector and the second optical detector is light emitted from the optical emitter and passing through the fluid sample.
[008] In another example, a method is described that includes emitting light into a fluid sample by means of an optical emitter. The exemplary method also includes detecting light emitted from the optical emitter and transmitted through the fluid sample by means of a first optical detector, detecting light emitted from the second optical emitter and diffused by the fluid sample by means of a second optical detector, and detect fluorescent emissions emitted by the fluid sample in response to light emitted by the optical emitter by means of a third optical detector. The exemplary method specifies that detecting light via the first optical detector and detecting light via the second optical detector further includes filtering the light so that substantially any light detected by the first optical detector and second optical detector is light emitted from the optical emitter and passing in the fluid sample.
[009] In another example, an optical sensor system is described that includes a housing that defines an optical analysis area through which a fluid sample travels for optical analysis. The housing includes an optical emitter assembly that supports an optical emitter configured to detect light emitted by the optical emitter and transmitted through the fluid sample, a second optical emitter assembly that supports a second optical detector configured to detect light emitted by the emitter optical and diffused by the fluid sample, and a third optical emitter assembly that supports a third optical detector configured to detect fluorescent emissions emitted by the fluid sample in response to light emitted by the optical emitter. The housing also includes an optical emitter window positioned between the optical emitter and the optical analysis area, a first optical detector window positioned between the first optical detector and the optical analysis area, a second optical detector window positioned between the second optical detector and the optical analysis area, and a third optical detector window positioned between the third optical detector and the optical analysis area. According to the example, the first optical detector window is positioned on an opposite side of the optical analysis area from the optical emitter window, the second optical detector window is positioned at an angle of approximately 90 degrees with respect to the window. of optical emitter, and the third optical detector window is positioned on an opposite side of the optical analysis area from the second optical detector window.
[010] The details of one or more examples are presented in the attached drawings and in the description below. Other aspects, objectives and advantages will be evident from the description and drawings, and from the claims. BRIEF DESCRIPTION OF THE DRAWINGS
[011] Figure 1 is a diagram illustrating an exemplary fluid system that includes an optical sensor according to examples in the description.
[012] Figure 2 is a block diagram illustrating an exemplary optical sensor that can be used in the exemplary fluid system of Figure 1.
[013] Figure 3 is a schematic drawing of the exemplary physical configuration of an optical sensor that can be used by the optical sensors in Figures 1 and 2.
[014] Figures 4 and 5 are cross-sectional drawings of the optical sensor in Figure 3.
[015] Figure 6 is a cross-sectional drawing of an exemplary alternative configuration of the optical sensor of Figure 3.
[016] Figure 7 is a cross-sectional drawing of an exemplary alternative configuration of the optical sensor of Figure 6. DETAILED DESCRIPTION
[017] The following detailed description is exemplary in nature and is not intended to limit the scope, applicability or configuration of the invention in any way. Instead, the following description provides some practical illustrations for implementing examples of the present invention. Examples of constructions, materials, dimensions and manufacturing processes are provided for selected elements, and all other elements employ what is known to those skilled in the art in the field of the invention. Those skilled in the art will recognize that many of the examples noted have a variety of suitable alternatives.
[018] Optical sensors are used in a variety of applications, including monitoring industrial processes. An optical sensor can be implemented as a handheld, portable device that is used to periodically analyze the optical characteristics of a fluid in an industrial process. Alternatively, an optical sensor can be installed online to continuously analyze the optical characteristics of a fluid in an industrial process. In each case, the optical sensor can optically analyze the fluid sample and determine different fluid characteristics, such as the concentration of one or more chemical species in the fluid.
[019] As an example, optical sensors are often used in industrial cleaning and sanitizing applications. During an industrial cleaning and sanitizing process, water is typically pumped through an industrial plumbing system to house the product plumbing system that resides in the pipes and any accumulated contamination within the pipes. The water may also contain a sanitizing agent that works to sanitize and disinfect the plumbing system. The cleaning and sanitizing process can prepare the plumbing system to receive new product and/or a different product than that previously processed in the system.
[020] An optical sensor can be used to monitor the characteristics of wash and sanitizing water flowing through a piping system during an industrial cleaning and sanitizing process. Either continuously or on an intermittent basis, water samples are drawn from the plumbing system and distributed to the optical sensor. Within the optical sensor, light is emitted to the water sample and used to assess the characteristics of the water sample. The optical sensor can determine whether waste product in the plumbing system has been sufficiently washed from the pipes, for example, by determining that there is little or no waste product in the water sample. The optical sensor can also determine the concentration of sanitizer in the water sample, for example, by measuring a fluorescent signal emitted by the sanitizer in response to light emitted in the water sample. If it is determined that there is an insufficient amount of sanitizer in the water sample to properly sanitize the plumbing system, the amount of sanitizer is increased to ensure proper sanitizing of the system.
[021] This description describes an optical sensor that, in some examples, includes multiple optical detectors providing multiple optical detection channels. Each optical detector is positioned at a different location within the optical sensor relative to an optical emitter. For example, an optical detector can be positioned on an opposite side of a fluid channel from the optical emitter to detect light emitted by the optical emitter and transmitted through the fluid within the fluid channel. Another optical detector can be positioned at a 90 degree angle to the optical emitter to detect light emitted by the optical emitter and diffused by fluid within the fluid channel. Yet another optical detector may be positioned at a different 90 degree angle with respect to the optical emitter to detect fluorescent emissions of light emitted by fluid within the fluid channel in response to light from the optical emitter.
[022] By configuring the optical sensor with multiple optical detection channels, the optical sensor can comprehensively monitor fluid samples from an industrial process. For example, when deployed as part of an online cleaning and sanitizing system, the optical sensor can receive fluid samples, such as wash water samples containing a sanitizing agent, and emit light in the fluid samples. The light detected by optical detectors other than the optical sensor in response to the emitted light may then vary depending on the characteristics of the fluid sample. For example, a fluid sample taken at the beginning of the cleaning process may contain a significant amount of optically opaque material (by eg waste product in a plumbing system) so that neither the transmission detector nor the diffusion detector receive any light. As fluid samples drawn from the system become progressively cleaner, the transmission detector becomes saturated with light. Around this point in the cleaning process, however, the diffusion detector can begin to detect light scattering within the fluid sample to allow continued monitoring of the fluid sample through the cleaning process. When the optical sensor still includes a detector that detects fluorescent emissions, the optical sensor can monitor the concentration of sanitizing agent in the water samples. In this way, the optical sensor can use the different optical detectors to monitor the progress of a cleaning and sanitizing operation and the concentration of a sanitizing agent used in the cleaning and sanitizing operation. Of course, this is merely an exemplary implementation of the optical sensor, and other implementations are possible and considered.
[023] While the optical sensor can have a variety of different configurations, in some examples the optical sensor is designed to have an optical emitter that is displaced from a center of a flow channel through which a fluid sample travels. For example, the optical emitter may be arranged to direct light adjacent to a wall of the flow channel rather than at a center of the flow channel. When so configured, light emitted in the flux channel may be less likely to reflect the inner surfaces of the flux channel than when light is directed at a center of the flux channel. This in turn can increase the signal strength detected by optical detectors, providing stronger signals to monitor the characteristics of the fluid under analysis. In applications where scale builds up on an optical detector during service, the ability to generate stronger signals can extend the length of time the optical sensor can remain in service between cleaning and maintenance.
[024] Exemplary optical sensor configurations will be described in more detail below with respect to Figures 2-6. However, an exemplary fluid system including an exemplary optical sensor system will first be described with respect to Figure 1.
[025] Figure 1 is a conceptual diagram illustrating an exemplary fluid system 100, which can be used to produce a chemical solution having fluorescent properties, such as sanitizing solution exhibiting fluorescent properties. Fluid system 100 includes an optical sensor 102, a reservoir 104, a controller 106, and a pump 108. The reservoir 104 can store a concentrated chemical agent that can be mixed with a diluent, such as water, to generate the chemical solution. . Optical sensor 102 is optically connected to fluid path 110 and is configured to determine one or more characteristics of the solution traveling through the fluid path. In operation, optical sensor 102 can communicate with controller 106, and controller 106 can control fluid system 100 based on fluid characteristic information generated by the optical sensor.
[026] Controller 106 is communicatively connected with optical sensor 102 and pump 108. Controller 106 includes processor 112 and memory 114. Controller 106 communicates with pump 108 via a connection 116. signals generated by optical sensor 102 are communicated to controller 106 via a wired or wireless connection, which in the example of Figure 1 is illustrated as a wired connection 118. Memory 109 stores software for running controller 106 and can also store data generated or received by processor 112, for example, from optical sensor 102. Processor 112 runs software stored in memory 114 to manage the operation of fluid system 100.
[027] As described in more detail below, the optical sensor 102 is configured to optically analyze a fluid sample flowing through the fluid path 110. In one example, the optical sensor 102 includes an optical emitter that emits light in the fluid sample. fluid and multiple optical detectors (eg, two, three, or more optical detectors) that measure light from the fluid sample. For example, optical sensor 102 may include an optical detector that is positioned to measure light emitted by the optical emitter and transmitted through the fluid sample. Optical sensor 102 may further include an optical detector that is positioned to measure light emitted by the optical emitter and scattered in a direction substantially orthogonal to the direction of emission. Optical sensor 102 may further include an optical detector that is positioned and configured to measure fluorescent emissions emitted by the fluid sample. In operation, optical detectors that measure optical transmittance and diffusion can be used to measure the optical transparency of the fluid sample, which can indicate the cleanliness of the system from which the fluid sample was extracted. The optical detector that measures fluorescence can be used to measure the concentration of a chemical species (eg sanitizer, corrosion control agent) in the fluid sample. By providing multiple optical detectors, optical sensor 102 can measure different optical characteristics of the fluid sample, such as the amount of optically opaque material in the fluid sample (e.g., contamination being cleaned from a system) and a concentration of a chemical species in the fluid sample. In addition, optical sensor 102 can measure the optical transparency of the fluid sample over a wide range of concentrations of the optically opaque material.
[028] Regardless of the number of optical detectors in optical sensor 102, in some additional examples described in more detail below, this optical sensor has an optical emitter that is positioned to direct light adjacent to a wall of an optical analysis area rather than in a center in the field of optical analysis. By moving the optical emitter so that it is offset from a center of the optical analysis area, the light emitted by the optical emitter may be less likely to reflect off internal surfaces in the optical analysis area. This in turn can increase the amount of light received by an optical detector in the optical sensor 102, increasing the power of the signal produced by the optical detector.
[029] In the example of Figure 1, the fluid system 100 is configured to generate a chemical solution having fluorescent properties. Fluid system 100 can combine one or more concentrated chemical agents stored within reservoir 104 with water or other dilution fluid to produce the chemical solutions. Exemplary chemical solutions that can be produced by fluid system 100 include, but are not limited to, cleaning agents, sanitizing agents, cooling water for industrial cooling towers, biocides such as pesticides, anti-corrosion agents, descaling agents, antifouling agents, wash detergents, clean-in-place type cleaners, floor coatings, vehicle care compositions, water care compositions, bottle wash compositions, and the like.
[030] The chemical solutions generated by the fluid system 100 can emit fluorescent radiation in response to optical energy directed to the solutions by the optical sensor 102. The optical sensor 102 can then detect the emitted fluorescent radiation and determine various characteristics of the solution, such as a concentration of one or more chemical compounds in the solution based on the magnitude of the fluorescent radiation emitted. In order to allow optical sensor 102 to detect fluorescent emissions, fluid generated by fluid system 100 and received by optical sensor 102 can include a molecule that exhibits fluorescent characteristics. In some examples it includes a polycyclic compound and/or a benzene molecule that has one or more electron-donating substituent groups such as, for example, -OH, -NH2 and -OCH3, which may exhibit fluorescent characteristics. Depending on the application, these compounds may be naturally present in chemical solutions generated by fluid system 100 due to the functional properties (e.g. cleaning and sanitizing properties) imparted to the solutions by the compounds.
[031] In addition to or in place of a naturally fluorescent compound, the fluid generated by fluid system 100 and received by optical sensor 102 may include a fluorescent label (which may also be referred to as a fluorescent label). The fluorescent label can be incorporated into the fluid specifically to impart fluorescent properties to the fluid. Exemplary fluorescent marker compounds include, but are not limited to, naphthalene disulfonate (NDSA), 2-naphthalenesulfonic acid, Acid Yellow 7,1,3,6,8-pyrenetetrasulfonic acid sodium salt, and fluorescein .
[032] Regardless of the specific composition of the fluid generated by fluid system 100, the system can generate fluid in any suitable manner. Under the control of controller 106, pump 108 can mechanically pump a defined amount to generate a liquid solution suitable for the intended application. Fluid path 110 can then drive the liquid solution to a desired discharge location. In some examples, the fluid system 100 may generate a flow of liquid solution continuously for a period of time such as, for example, a period greater than 5 minutes, a period greater than 30 minutes, or even a period greater than 24 hours . Fluid system 100 can generate solution continuously where the flow of solution passing through fluid path 110 can be substantially or entirely uninterrupted for a period of time.
[033] For some example, monitoring the characteristics of the fluid flowing through the fluid path 110 can help ensure that the fluid is properly formulated for an intended downstream application. Monitoring the characteristics of the fluid flowing through the fluid path 110 can also provide feedback information, for example, to adjust parameters used to generate new fluid solution. For these and other reasons, fluid system 100 can include a sensor to determine the various characteristics of the fluid generated by the system.
[034] In the example of Figure 1, the fluid system 100 includes the optical sensor 102. The optical sensor 102 is configured to determine one or more characteristics of the fluid flowing through the fluid path 110. Exemplary characteristics include, but do not are limited to, the concentration of one or more chemical compounds within the fluid (for example, the concentration of one or more active agents added from reservoir 104 and/or the concentration of one or more materials being washed from the plumbing in the fluid system 100), fluid temperature, fluid conductivity, fluid pH, flow rate at which fluid moves through the optical sensor, and/or other fluid characteristics that can help ensure the system from which the fluid sample being analyzed is operating properly. Optical sensor 102 communicates the detected characteristic information to controller 106 via connection 118.
[035] In response to receiving the detected characteristic, the processor 112 of the controller 106 may compare the determined characteristic information to one or more limits stored in memory 114 such as one or more concentration limits. Based on the comparison, controller 106 may adjust fluid system 100, for example, so that the detected characteristic matches the target value for the characteristic. In some examples, controller 106 starts and/or stops pump 108 or increases and/or decreases the flow rate of pump 108 to adjust the concentration of a chemical that flows through fluid path 110. Start pump 108 or increase the pump 108 operating flow can increase the concentration of the chemical in the fluid. Stopping pump 108 or decreasing the operating flow of pump 108 can decrease the concentration of chemical in the fluid. In some examples, controller 106 can control the flow of water that mixes with a chemical compound in reservoir 104 based on particular characteristic information, for example, starting or stopping a pump that controls the flow of water or increasing or decreasing a flow rate in that the pump operates. Although not illustrated in the exemplary fluid system 100 of Figure 1, controller 106 may also be communicatively coupled with a heat exchanger, and/or cooler to adjust the temperature of fluid flowing through fluid path 110 based in feature information from the optical sensor 102.
[036] Optical sensor 102 can be implemented in a number of different ways in fluid system 100. In the example shown in Figure 1, optical sensor 102 is positioned in line with fluid trajectory 110 to determine a characteristic of the fluid that flows through the fluid path. In other examples, a pipe, tube, or other conduit may be connected between the fluid path 110 and a flow chamber of the optical sensor 102. In such examples, the conduit may fluidly connect the flow chamber (e.g., an inlet of the flow chamber) of the optical sensor 102 in the fluid path 110. When fluid moves through the fluid path 110, a portion of the fluid may enter the conduit and pass adjacent a sensor head positioned within a chamber. of fluid, thereby allowing the optical sensor 102 to determine one or more characteristics of the fluid flowing through the fluid path. When implemented to receive fluid directly from fluid path 110, optical sensor 102 can be characterized as an online optical sensor. After passing through the flow chamber, the analyzed fluid may or may not be returned to the fluid path 110, for example, through another conduit connecting an outlet of the flow chamber to the fluid path.
[037] In still other examples, the optical sensor 102 can be used to determine one or more characteristics of a stationary volume of fluid that does not flow through a flow chamber of the optical sensor. For example, optical sensor 102 can be implemented as an offline monitoring tool (eg, as a manual sensor), which requires filling the optical sensor with a fluid sample manually extracted from fluid system 100.
[038] The fluid system 100 in the example of Figure 1 also includes the reservoir 104, the pump 108 and the fluid path 110. The reservoir 104 can be any type of container that stores a chemical agent for subsequent dispensing that includes, for example, a tank, a bag, a bottle, and a box. Reservoir 104 can store a liquid, a solid (e.g., powder), and/or a gas. Pump 108 may be any form of pumping mechanism that supplies fluid from reservoir 104. For example, pump 108 may comprise a peristaltic or other form of continuous pump, a positive displacement pump, or any other type of pump suitable for the particular application. In instances where reservoir 104 stores a solid and/or gas, pump 108 may be replaced with a different type of metering device configured to deliver the chemical agent gas and/or solid to a desired discharge location. Fluid path 110 in fluid system 100 can be any type of flexible or inflexible tubing, conduit, or conduit.
[039] In the example of Figure 1, the optical sensor 102 determines a characteristic of the fluid flowing through the fluid path 110 (for example, concentration of a chemical compound, temperature or similar), and the controller 106 controls the fluid system 100 based on the determined characteristic and, for example, a target characteristic stored in memory 114. Figure 2 is a block diagram illustrating an example of an optical sensor 200 that determines a characteristic of a fluid medium. Sensor 200 can be used as optical sensor 102 in fluid system 100, or sensor 200 can be used in applications other than fluid system 100.
[040] Referring to Figure 2, sensor 200 includes a controller 220, one or more optical emitters 222 (referred to herein as "optical emitter 222"), and one or more optical detectors which, in the illustrated example, is shown to include three optical detectors: the first optical detector 224A, the second optical detector 224B, and the third optical detector 224C (collectively referred to herein as “optical detectors 224”). Sensor 200 also includes optical filters 225A-225D (collectively “optical filters 225”) positioned between optical emitter 222/optical detectors 224 and optical analysis area 230. Controller 220 includes a processor 226 and a memory 228. In operation , the optical emitter 222 directs light onto a fluid sample filling the optical analysis area 230. The fluid sample may be stationary within the optical analysis area 230. Alternatively, the fluid sample may be flowing through the optical analysis area. 230. Independently, in response to light emitted by optical emitter 222, one or more optical detectors 224 can detect light emanating from or passing through the fluid. The characteristics of the fluid in optical analysis area 230 (for example, the concentration of different chemical species in the fluid) can dictate whether light emitted by optical emitter 222 reaches any or all of the optical detectors 224. Additionally, the position and configuration of each of the optical detectors 224 with respect to the optical emitter 222 can influence whether the optical detectors detect light emitted by the optical emitter 222 during operation.
[041] In some examples, the optical sensor 200 includes additional emitters and/or detectors. For example, optical sensor 200 may include a fourth detector 224D that functions as a reference detector. In operation, fourth detector 224D can receive unfiltered light from optical emitter 222 to monitor the output intensity of the optical emitter. Controller 220 can adjust measurements made by optical detectors 224A-224C to compensate for changes in the output of optical emitter 222, as determined based on data from the fourth optical detector 224D.
[042] Although the sensor 200 is generally described as being an optical sensor, the sensor may include one or more non-optical sensor components to measure additional properties of a fluid flowing through the sensor. In the example of Figure 2, sensor 200 includes a temperature sensor 221, a pH sensor 229, a conductivity sensor 231, and a flow sensor 232. The temperature sensor 221 can detect a temperature of the fluid flowing through the sensor; the 229 pH sensor can determine a pH of the fluid flowing through the sensor; and conductivity sensor 231 can determine an electrical conductivity of the fluid flowing through the sensor. The 232 flow sensor can monitor the flow rate at which fluid is flowing through the sensor.
[043] In the configuration of sensor 200, the first optical detector 224A, a second optical detector 224B, and a third optical detector 224C are positioned on a different side of the optical analysis area 230 than the optical emitter 222. optical detector 224A is positioned on an opposite side of the optical analysis area 230 than the optical emitter 222 (eg directly across the optical analysis area from the optical emitter). The second optical detector 224B is positioned at an angle of approximately 90 degrees to the optical emitter 222. Additionally, the third optical detector 224C is positioned on an opposite side of the optical analysis area 230 of the second detector [optical 224B and also on a angle of approximately 90 degrees with respect to the optical emitter 222.
[044] The first optical detector 224A and the second optical detector 224B in the example of Figure 2 are configured to detect light directed by the optical emitter 222 into the fluid in optical analysis area 230 and passing through the fluid (for example, both by transmission direct as it can diffusion/reflection). The first optical detector 224A can detect light transmitted directly through the optical analysis area in a substantially linear transmission path. Second optical detector 224B can detect light transmitted from optical emitter 222 and diffused/reflected by fluid within optical analysis area 230. For example, second optical detector 224B can detect light transmitted from optical emitter 222 and diffused into a orthogonal (for example, approximately 90 degrees) with respect to the direction of light emission. The third optical detector 224C in the example of Figure 2 is configured to detect fluorescent emissions generated by the fluid in optical analysis area 230 in response to light from optical emitter 222.
[045] In operation, the first optical detector 224A and/or second optical detector 224B can be used to determine a concentration of a non-fluorescent species in the fluid sample under analysis while the third optical detector 224C can be used to determine a concentration of a fluorescent species in the fluid sample under analysis. The amount of light detected by each of the detectors 224 may be associated with the different concentration levels of chemical stored in the memory 228. Accordingly, during use, the processor 226 may receive signals from each of the optical detectors 224 representative of the amount. of light detected by each optical detector, comparing and/or processing the signals based on calibration information stored in memory 228, and determining the concentration of one or more chemical species in the fluid sample under analysis. By providing a first optical detector 224A and a second optical detector 224B on different sides of the optical analysis area 230, the sensor 200 can determine a concentration for a non-fluorescent species over a wider range of concentrations than if the sensor includes only one of the first detector 224A optical and 224B second optical detector.
[046] As an example, the sensor 200 can be used to monitor wash water which is used to level a piping system containing an optically opaque material such as milk. The sensor 200 can receive and evaluate wash water samples throughout the wash process. At the beginning of the wash process, the sensor 200 can receive a fluid sample that contains a high concentration of the optically opaque material. When optical emitter 222 directs light into this fluid sample, neither the first optical detector 224A nor the second optical detector 224B can detect any light, indicating that there is a high concentration of optically opaque material in the sample. As the optically opaque material begins to clean from the plumbing system, the sensor 200 can receive a fluid sample that contains a reduced amount of optically opaque material. When optical emitter 222 directs light on this fluid sample, first optical detector 224A may detect some light that transmits through the fluid sample and second optical detector 224B may or may not detect light that diffuses within the fluid sample. Sensor 200 can determine a concentration of the optically opaque material, for example, based on a magnitude of the signal received from the first optical detector 224A and calibration data stored in memory.
[047] As the washing process continues in this example, the optically opaque material may still clean from the plumbing system, for example, until the plumbing system is substantially or entirely free of the optically opaque material. Consequently, the sensor 200 can receive an additional fluid sample that contains an additional reduced amount of optically opaque material. When optical emitter 222 directs light into this fluid sample, the amount of light passing through the fluid sample can saturate first optical detector 224A because the optical transparency of the fluid sample is so great. However, the second optical detector 224B can detect light that diffuses into the fluid sample. The amount of light that scatters can be dependent, for example, on the concentration of the optically opaque material in the fluid sample and/or the turbidity of the fluid sample. Sensor 200 can determine a concentration of the optically opaque material, for example, based on a magnitude of the signal received from the second optical detector 224B and calibration data stored in memory.
[048] In cases where the wash liquid also includes a fluorescent molecule, for example, associated with a sanitizing agent, the third optical detector 224C can detect the fluorescent emissions emanating from the fluid sample in response to light emitted by the optical emitter 222. The sensor 200 can then determine a concentration of the fluorescent material, for example, based on a magnitude of the signal received from the third optical detector 224A and calibration data stored in memory. In this way, sensor 200 can provide multiple detection channels associated with multiple optical detectors. Different optical detectors can be configured and arranged with respect to optical emitter 222 to detect light traveling in different directions and/or different light wavelengths. It should be appreciated that the foregoing discussion of a washing process is merely an exemplary implementation of sensor 200, and the description is not limited in this regard.
[049] To control the wavelengths of light emitted by optical emitter 222 and detected by optical detectors 224, sensor 200 can include optical filters 225. Optical filters 225 can filter wavelengths of light emitted by optical emitter 222 and/ or received by optical detectors 224, for example, so that only certain wavelengths of light are emitted in the optical analysis area 230 and/or received from the optical analysis area. In the example of Figure 2, a first optical detection filter 225A is positioned between the first optical detector 224A and optical analysis area 230; a second optical detection filter 225B is positioned between the second optical detector 224B and the optical analysis area; a third optical detection filter 225C is positioned between the third optical detector 224C and the optical analysis area; and an optical emission filter 225D is positioned between the optical emitter 222 and the optical analysis area. In operation, light emitted by optical emitter 222 passes through optical emission filter 225D. The 225D optical emission filter can filter or remove certain wavelengths of light emitted by the optical emitter so that only select wavelengths of light pass through the filter. Likewise, optical detection filters 225a-225C can filter or remove certain wavelengths of light so that only select wavelengths of light are received by optical detectors 224. When used, optical reference detector 224D can be positioned in a variety of locations within sensor 200. In different examples, optical reference detector 224D may be positioned to receive a portion of the light emitted by optical emitter 222 but unfiltered, a portion of the light reflected by filter 225D, and/or a portion of the light transmitted through filter 225D from optical emitter 222.
[050] The wavelengths of light that optical filters 225 are designed to filter may vary, for example, depending on the expected chemical composition of the fluid in optical analysis area 230 and the design parameters of optical emitter 222 and optical detectors 224 in applications where the first optical detector 224a and the second optical detector 224B are configured to detect light that passes through a fluid sample, the first optical detection filter 225A and the second optical detection filter 225B may be configured to pass the same wavelengths of light passing through the 225D optical emission filter while rejecting all other wavelengths of light. In contrast, the third optical detection filter 225C can be configured to reject (e.g. filter) those wavelengths of light emitted by the optical emitter 222 and pass different wavelengths of light that correspond with the part of the spectrum in which it emits a fluorescent molecule in the fluid sample. The third optical detection filter 225C can filter different wavelengths of light than the optical emission filter 225D because when the optical emitter 222 directs light at a frequency (eg ultraviolet frequency) into the fluid flowing through the optical analysis area 230, fluorescent molecules can emit light energy at a different frequency (eg, visible light frequency, different ultraviolet frequency).
[051] In practice, the first optical filter 225A, the second optical filter 225B, and the optical emission filter 225D can be of the same type of filter that filters the same wavelengths of light. In contrast, the third optical filter 225C can be configured to reject (e.g. filter) all wavelengths of light that can pass through the first optical filter 225A, second optical filter 225B, and optical emission filter 225D and allow the passage of wavelengths of light in a part of the spectrum where it is expected to emit a fluorescent molecule in the fluid sample. For example, the first optical filter 225A, the second optical filter 225B, and an optical emission filter 225D can be configured to filter light wavelengths greater than 300 nanometers so that only light lengths less than 300 nanometers can pass through of the filters. According to this example, the third optical detector filter 225C can filter light wavelengths smaller than 300 nanometers so that only light wavelengths larger than 300 nanometers can pass through the filter.
[052] By configuring the first optical filter 225A and the second optical filter 225B to be the same optical filter as the optical emission filter 225D, substantially any light (e.g., all light) detected by the first optical detector 224a and the second detector Optical 224B during operation will be light emitted by optical emitter 222 which passes through optical emission filter 225D and the fluid sample. Additionally, by configuring the third optical filter 225C to reject the wavelengths of light passing through the optical emission filter 225D, substantially any light (e.g., all light) detected by the third optical detector 224C will be the light emitted by fluorescent molecules in the fluid sample. In contrast, if the first optical filter 225A and the second optical filter 225B pass different wavelengths of light than the optical emission filter 225D, the first optical detector 224A and the second optical detector 224B can detect light from sources other than the optical emitter 222, as does the light emitted by fluorescent molecules. Likewise, if the third optical filter 225C passes wavelengths of light emitted by the optical emitter 222, the third optical detector 224C can detect light from sources other than the fluorescent molecules, such as light emitted by the optical emitter itself.
[053] In some examples, all three filters 225A, 225B, 225C are configured to reject the wavelengths of light that pass through the optical emission filter 225D so that substantially any light, (eg, all of the light) detected by all three optical detectors 224A, 224B, 224C will be the light emitted by fluorescent molecules in the fluid sample. Such a setup can be used to detect multiple different fluorescence spectral areas (eg, three) to measure multiple spectral components simultaneously. For example, signals from one or two detectors that measure different spectral areas can be used to compensate for interference from compounds present in a fluid and produce fluorescence by masking a desired signal from the third detector. As an example, the fluorescence of natural substances such as milk can be present in a fluid and can interfere with the fluorescence emitted from a chemical compound in the fluid (eg, a cleaning agent, sanitizing agent, marker) whose concentration is being measured by sensor 200. To help compensate for this fluorescence masking, different spectral areas (eg, different wavelengths) of the fluorescent emissions from the fluid can be detected and used to computationally compensate for interference.
[054] While sensor 200 in the example in Figure 2 includes optical filters 225, in other examples sensor 200 may not include optical filters 225 or may have a different number or arrangement of optical filters. For example, the physical filter positioned between optical emitter 222, and optical analysis area 230 may not be necessary if the laser light source is used providing a highly monochromatic excitation beam. Additionally, some or all of the 225A-225C optical filters for the detectors may not be needed if the spectral sensitivity of the detector(s) provides adequate excitation light and/or fluorescent light rejection. As an example, if sensor 200 is configured to measure delayed fluorescence or scattering, time filtering can be used instead of physical spectral filtering. In such cases, optical filters 225 may be programs stored in memory 228 that are executed by processor 226 to electronically filter data generated by sensor 200.
[055] Sensor 200 in Figure 2 includes optical emitter 222. Optical emitter 222 can emit optical energy in a fluid present with optical analysis area 230. In some examples, optical emitter 222 emits optical energy over a range of lengths of wave. In other examples, optical emitter 222 can emit at two, three, four, or more distinct wavelengths. Additionally, although sensor 200 is only illustrated as having only one [single optical emitter, in other applications, sensor 200 may have multiple (e.g. two, three, four or more) optical emitters.
[056] In one example, the optical emitter 222 emits light within the ultraviolet (UV) spectrum and/or the visible range of the spectrum. Light within the UV spectrum can include wavelengths in the range of approximately 200 nm to approximately 400 nanometers. Light within the visible spectrum can include wavelengths in the range of approximately 400nm to approximately 700nm. Light emitted by optical emitter 222 is directed onto the fluid within optical analysis area 230. In response to receiving optical energy, fluorescent molecules within the fluid can excite, causing the molecules to produce fluorescent emissions. For example, light directed into the fluid by optical emitter 222 can generate fluorescent emissions by exciting electrons from fluorescent molecules within the fluid, causing the molecules to emit energy (eg, fluorescence). Fluorescent emissions, which may or may not be at a different frequency than the energy emitted by optical emitter 222, can be generated as excited electrons within fluorescent molecules change energy states. The energy emitted by the fluorescent molecules can be detected by the third optical detector 224C.
[057] Optical emitter 222 can be implemented in a variety of different ways within sensor 200. Optical emitter 222 can include one or more light sources to excite molecules within the fluid. Exemplary light sources include light-emitting diodes (LEDs), lasers and lamps. In some examples, as discussed above, optical emitter 222 includes an optical filter to filter light emitted by the light source. The optical filter can be positioned between the light source and the fluid and be selected to pass light within a certain wavelength range. In some additional examples, the optical emitter includes a collimator, eg collimating lens, cap or reflector, positioned adjacent to the light source to collimate the light emitted from the light source. The collimator can reduce the divergence of light emitted from the light source, reducing optical noise.
[058] The sensor 200 also includes optical detectors 224. The optical detectors 224 may include at least one optical detector that detects fluorescent emissions emitted by excited molecules within the optical analysis area 230 (for example, the optical detector 224C) and at least an optical detector that detects light emitted by optical emitter 222 and passing through the fluid in the optical analysis area (e.g., first optical detector 224A and/or second optical detector 224B). In operation, the amount of optical energy detected by each optical detector of optical detectors 224 may depend on the fluid contents within the optical analysis area 230. Whether the optical analysis area contains a fluid solution that has certain properties (e.g., certain chemical compound and/or a certain concentration of a chemical species), each optical detector of optical detectors 224 can detect a certain level of fluorescent energy emitted by the fluid and/or transmitted through or diffused by the fluid. However, if the fluid solution has different properties (eg, a different chemical compound and/or a different concentration of the chemical species), each optical detector of optical detectors 224 can detect a different level of fluorescent energy emitted by the fluid and/ or a different level of optical energy transmitted through or diffused by the fluid. For example, if a fluid within optical analysis area 230 has a first concentration of a fluorescent chemical compound(s), the third optical detector 224C can detect a second magnitude of fluorescent emissions that is greater than the first magnitude.
[059] Each optical detector from optical detectors 224 may be implemented in a variety of different ways within the sensor 200. Each optical detector from optical detectors 224 may include one or more photodetectors such as, for example, photodiodes or photomultipliers, to convert signals optical signals into electrical signals. In some examples, each optical detector of optical detectors 224 includes a lens positioned between the fluid and the photodetector to focus and/or shape optical energy received from the fluid. In addition, while sensor 200 in the example of Figure 2 includes three optical detectors 224A-224C, in other examples, sensor 200 may include fewer optical detectors (for example, a single optical detector such as 224B or 224C) or more optical detectors ( for example, four, five, or more). It should be appreciated that the description is not limited to a sensor having any specific number of optical detectors.
[060] The sensor 200 in the example in Figure 2 also includes the temperature sensor 221. The temperature sensor 221 is configured to detect a temperature of a fluid passing through a flow chamber of the sensor. In various examples, temperature sensor 221 may be a bimetal mechanical temperature sensor, an electrical resistance temperature sensor, an optical temperature sensor, or any other suitable type of temperature sensor. Temperature sensor 221 can generate a signal that is representative of the magnitude of the detected temperature.
[061] Controller 220 controls the operation of optical emitter 222 and receives signals relating to the amount of light detected by each optical detector of optical detectors 224. Controller 220 also received signals from temperature sensor 221 with respect to the fluid temperature in contact with the sensor, 229 pH sensor signals with reference to the pH of the fluid in contact with the sensor, 231 conductivity sensor signals referring to the conductivity of the fluid in contact with the sensor, and 232 flow sensor signals with reference to the rate at which liquid is flowing through the sensor. In some examples, controller 220 further processes signals, for example, to determine a concentration of one or more chemical species within the fluid passing through fluid channel 230.
[062] In one example, controller 220 controls optical emitter 222 to direct radiation into a fluid and further controls each optical detector of optical detectors 224 to detect fluorescent emissions emitted by the fluid and/or light transmitted through or diffused by the fluid. Controller 220 then processes the light detection information. For example, controller 220 may process light detection information received from third optical detector 224C to determine a concentration of a chemical species in the fluid. In cases where a fluid includes a fluorescent label, a concentration of a chemical species of interest can be determined based on a determined concentration of the fluorescent label. Controller 220 can determine a fluorescent label concentration by comparing the magnitude of fluorescent emissions detected by the third optical detector 224C of a fluid having an unknown concentration of the label to the magnitude of fluorescent emissions detected by the third optical detector 224C of a fluid having a known concentration of the bookmark. Controller 200 can determine the concentration of a chemical species of interest using Equations (1) and (2) below:

[063] In Equations (1) and (2) above, Cc is a current concentration of the chemical species of interest, Cm is a current concentration of the fluorescent label, C0 is a nominal concentration of the chemical species of interest, Cf is a nominal concentration of the fluorescent marker, Km is a slope correction coefficient, Sx is a current fluorescent measurement signal, and Z0 is a zero offset. Controller 220 can further adjust the determined concentration of the chemical species of interest based on the temperature measured by the temperature sensor.
[064] Controller 220 may also process light detection information received from first optical detector 224A and/or second optical detector 224B to determine other aspects of the fluid under analysis, such as a concentration of a non-fluorescent chemical species in the fluid. Controller 220 can determine the concentration of the non-fluorescent chemical species by comparing the magnitude of light detected by the first optical detector 224A and/or second optical detector 224B of a fluid having an unknown concentration of the species to the magnitude of light detected by the first optical detector 224a and/or second optical detector 224B from a fluid having a known concentration of the species. Controller 220 can compare the determined concentration to one or more thresholds stored in memory 28. For example, when controller 220 is used to monitor wash water, the controller may compare the determined concentration of the non-fluorescent species to one or more thresholds. stored in memory. Controller 220 may further adjust the wash process (e.g. to start, stop or adjust wash water rates) based on the comparison.
[065] The optical analysis area 230 in the sensor 200 may be a region of the sensor where fluid can reside and/or pass through for optical analysis. In one example, optical analysis area 230 comprises a tube of optically transparent material (eg, glass, plastic, sapphire) through which light can be emitted and received. The tube can define an inside diameter and an outside diameter, where a tube wall thickness separates the inside diameter from the outside diameter. In another example, optical analysis area 230 is a region of a flow chamber housing through which liquid flows for optical analysis. Although optical analysis area 230 is conceptually illustrated as being square in cross-sectional shape, the area can define any polygonal (eg triangle, hexagon) or arcuate (eg circular, elliptical) or even combinations of polygonal shapes. and arched. In addition, while the optical analysis area 230 can be of any size, in some applications, the optical analysis area is comparatively small to minimize the amount of fluid that is needed to fill the optical analysis area. For example, optical analysis area 230 can define a larger cross-sectional dimension (eg, diameter) less than 15 millimeters (mm), such as less than 10 mm, or less than 5 mm. In one example, optical analysis area 230 is a tube having an outside diameter ranging from approximately 10 mm to approximately 4 mm, a wall thickness ranging from approximately 3 mm to approximately 1 mm, and an inside diameter ranging from approximately 9 mm to approximately 1 mm.
[066] Memory 228 of sensor 200 stores software and data used or generated by controller 220. For example, memory 228 may store data used by controller 220 to determine a concentration of one or more chemical components within the fluid being monitored by the sensor 200. in some examples, memory 228 stores data in the form of an equation that relates light detected by optical detectors 224 to a concentration of one or more chemical components.
[067] Processor 226 runs software stored in memory 228 to perform the functions assigned to sensor 200 and controller 220 in this description. Components described as processors within controller 220, controller 106, or any other device described in this description may include one or more processors, such as one or more microprocessors, digital signal processors (DSPs), application-specific integrated circuits ( ASICs), programmable field gate arrays (FPGAs), programmable logic circuitry, or the like, alone or in any suitable combination.
[068] Sensor 102 (Figure 1) and sensor 200 (Figure 2) can have a number of different physical configurations. Figure 3 is a schematic drawing of an exemplary configuration of a sensor 300, which can be used by sensor 102 and sensor 200. Sensor 300 includes a flow chamber 302, a light emission/detection assembly 304, a flow chamber top cover 306, and a flow chamber bottom cover 308. has an inlet 310 that receives fluid (e.g., from the fluid path 110 in Figure 1), an outlet 312 that holds the fluid after optical analysis within the flow chamber, and an optical analysis area 314 between the inlet and the exit.
[069] The light emission/detection assembly 304 is shown out of and insertable into the flow chamber 302. The light emission/detection assembly 304 includes an optical emitter assembly 316 that supports an optical emitter, a first optical detector assembly 318 that supports a first optical detector, a second optical detector assembly 320 that supports a second optical detector, and a third optical detector assembly 322 that supports a third optical detector. In operation, the optical emitter supported by the optical emitter assembly 316 can emit optical energy through a first optical window 324 in optical analysis area 314. This first optical window 324 may be referred to as an optical emitter window. The first optical detector supported by the first optical detector assembly 318 can detect light emitted by the optical emitter, and transmitted through the optical analysis area 314, and received through a second optical window 326. This second optical window 326 may be referred to as a first optical detector window. The second optical detector supported by the second optical detector assembly 320 can detect light emitted by the optical emitter and diffused in a direction substantially orthogonal to the emission direction through a third optical window 328. This third optical window 328 may be referred to as a second optical window. optical detector window. In addition, the third optical detector supported by the third optical detector assembly 322 can detect fluorescent emissions from within the optical analysis area 314 through a fourth optical window 330. This fourth optical window 330 may be referred to as a third optical detector window .
[070] Optical windows 324, 326, 328 and 330 are shown as being positioned outside the flow chamber 302 and insertable into the flow chamber. When inserted into the flow chamber, the optical windows can define fluid-proof optically transparent regions through which light can be emitted into the optical analysis area 314 and detected from the optical analysis DCE area. Optical windows 324, 326, 328, and 330 may or may not include a lens, prism, or other optical device that transmits and refracts light. In the illustrated example, optical windows 324, 326, 328, and 330 are formed by a ball lens positioned within an insertion channel extending through flow chamber 302. The ball lens can be fabricated from glass, sapphire, or other optically materials. suitable transparent sheets. In different examples, the optical windows 324, 326, 328 and 330 may not be removable but may instead be permanently formed/connected with the flow chamber 302.
[071] In addition to the flow chamber 302 and light emission/detection assembly 304, the sensor 300 in the example of Figure 3 also includes an electrical connection panel 332, an electrical cable 334, and a temperature sensor 336. electrical connection panel 332 electrically couples optical emitter assembly 316, first optical detector assembly 318, second optical detector assembly 320, and third optical detector assembly 322 to electrical conduit 334. Electrical cable 334 can carry electrical signals transmitted to or generated by sensor 300. Electrical cable 334 may or may not also conduct power to sensor 300 to drive the various components of the sensor. Temperature sensor 336 can detect a temperature of fluid entering the optical analysis area and generate a signal that corresponds to the detected temperature.
[072] Figure 4 is a cross-sectional illustration of sensor 300 taken in a ZY plane indicated in Figure 3 that divides the third optical window 328 and the fourth optical window 330 in two. Equal components of sensor 300 in Figures 3 and 4 are identified by like reference numbers. As shown in Figure 4, optical windows 324, 328, and 330 are positioned within flow chamber 302 to direct light to or receive light from optical analysis area 314. Optical analysis area 314 is a flow path defined in the chamber. flow path 302 through which fluid can travel beyond the optical windows of the sensor for optical analysis. In the illustrated example, optical windows 324, 328, and 330 are positioned at a coplanar location (i.e., coplanar in the XY plane indicated in Figure 4) along the optical analysis area 314, for example, so that a common plane becomes extends through a geometric center of optical windows 324, 328, and 330. Second optical window 326 (not shown in Figure 4) can be positioned in the same plane as optical windows 324, 328, and 330. Position optical windows 324, 326 , 328 and 330 in a common plane may be useful so that optical detectors positioned behind optical windows 326, 328 and 330 receive light from the same plane as the optical emitter positioned behind optical window 324 emits. If optical windows 326, 328 and 330 are displaced from the plane in which optical window 324 is positioned, the amount of light detected, and therefore the power of the signal generated, by detectors positioned behind the windows may be reduced compared to a coplanar location.
[073] While optical sensor 300 is illustrated as having only a single row of optical windows 324, 326, 328 and 330 positioned in a common plane to optical emitter 222 and optical detectors 224, in examples where the optical sensor has more optical emitters and/or detectors, the sensor may have one or more additional rows of optical windows. For example, optical sensor 300 may include two, three, or more vertically stacked rows (eg, in the Z direction indicated in Figure 4) of optical windows, where the optical windows in each row are coplanar (ie, coplanar in the XY plane indicated in Figure 4). In one example, optical sensor 300 includes three rows of optical windows, where each row includes an optical emitter and three optical detectors. As another example, optical sensor 300 includes two rows of optical windows, where each row includes two optical emitters and two optical detectors. Increasing the number of optical emitters and/or optical detectors in sensor 300 can increase the number of wavelengths of light emitted in and/or detected from the fluid flowing through fluid path 314.
[074] Figure 4 also illustrates temperature sensor 336. Temperature sensor 336 is positioned within a common cavity 335 of optical housing 302 that contains optical detector 358. Temperature sensor 336 extends through a lower portion of the cavity so that the sensor contacts the fluid flowing through the optical sensor to detect a temperature of the fluid. In the example, temperature sensor 336 is formed into a circuit board 339, which is the same circuit board that contains optical detector 358. That is, a single circuit board contains the same electronics for the temperature sensor as the optical detector. Such configuration can be useful to make the optical sensor more compact.
[075] In some examples, sensor 300 includes non-optical sensor components, such as a pH sensor, a conductivity sensor, and a flow sensor. When used, each of the non-optical sensors can be formed into a common circuit panel with one of the optical emitters (eg the electronics for one of the optical emitters) and/or optical detectors (eg electronics for the optical detectors) of the sensor positioned within a common cavity of the housing. For example, the electronics for the pH sensor can be formed in the same circuit board as an optical detector, the electronics for the conductivity sensor can be formed in the same circuit board as a different optical detector, and the electronic components for temperature sensor 336 may be formed in circuit board 339 of yet another optical detector. Each sensor may extend through a lower portion of a respective optical housing cavity 102 (for example, as shown for temperature sensor 336 in Figure 4) to contact fluid flowing through the sensor. When used, the flow sensor can also be formed on the same circuit board as one of the optical emitters/optical detectors. As an example, the electronics for a differential pressure flow sensor can be formed on the same circuit board as one of the optical emitters/optical detectors with the flow sensor positioned in region 337 to measure flow adjacent to output 312.
[076] Figure 5 is a cross-sectional illustration of sensor 300 taken along line A-A indicated in Figure 4. Again, like components of sensor 300 in Figures 3-5 are identified by like reference numerals. As shown in this example, an optical emitter 350 is positioned (e.g., centered) behind the first optical window 324, and a first optical detector 352 is positioned (e.g., centered) behind the second optical window 326. The first detector Optical 352 is positioned on an opposite side of optical analysis area 314, for example, so that light emitted from optical emitter 350 traveling in a linear or substantially linear direction and transmitted through the fluid in the optical analysis area is received by the first optical detector. In some examples, the first optical detector 352 is positioned on an opposite side of the optical analysis area 324 such that an axis 380, located in a common plane of optical windows 324, 326, 328, 330 (eg, an XY plane common indicated in Figures 4 and 5) and extending through a geometric center of the first optical window 324, intersects the second optical window 326 through the optical analysis area 314. For example, the axis 380 extending through a geometric center of the first optical window 324 may intersect an axis 382 which is located in the common plane of optical windows 324, 326, 328, 330 and which extends through a geometric center of second optical window 326. In such a configuration, second optical window 326 may be positioned directly across the optical analysis area 314 from the first optical window 324. In other examples, as described in more detail below with respect to Figure 6, the second optical window 326 can be positioned across the an area. optical analysis 314 from the first optical window 324, but can be deviated from the first optical window (eg, in the positive or negative Y direction indicated in Figure 5).
[077] In the example of Figure 5, sensor 300 also includes a second optical detector 356 positioned (e.g., centered) behind the third optical window 328 and a third optical detector 358 positioned (e.g., centered) behind the fourth optical window 330. The second optical detector 356 is positioned at an angle of approximately 90 degrees with respect to the optical emitter 350, for example, so that light emitted from the optical emitter 350 traveling in a linear or substantially linear direction must diffuse in, a generally orthogonal direction and be transmitted through the fluid in the optical analysis area to be received by the second optical detector. The third optical detector 358 is positioned opposite the second optical detector 356 through the optical analysis area 314. The third optical detector 358 is also positioned at an angle of approximately 90 degrees with respect to the optical emitter 350, for example, so that the light emitted from optical emitter 350 traveling in a linear or substantially linear direction must diffuse in a generally orthogonal direction and be transmitted through the fluid in the optical analysis area in order to be received by the third optical detector.
[078] In some examples, the second optical detector 356 is positioned at an angle of approximately 90 degrees with respect to the optical emitter 350 such that an axis 384 in a common plane of optical windows 324, 326, 328, 330 (for example , a common XY plane indicated in Figures 4 and 5) and extending through a geometric center of the third optical window 328 intersects axis 380 at an angle of approximately 90 degrees (eg an angle ranging from 60 degrees to 120 degrees) . The third optical detector 358 can be positioned at an angle of approximately 90 degrees with respect to optical emitter 350 so that an axis 386 is in a common plane of optical windows 324, 326, 328, 330 (eg a common XY plane indicated in Figures 4 and 5) and extending through a geometric center of the fourth optical window 330 intersects axis 380 at an angle of approximately 90 degrees (for example, an angle ranging from 60 degrees to 120 degrees). In different examples, axis 384 and axis 386 may intersect each other so that the third optical window is positioned directly opposite the fourth optical window, or axis 384 and axis 386 may be offset from each other (for example, in the positive or negative XY direction indicated in Figure 5), so that the third optical window is offset from the fourth optical window. Positioning the third optical window 328 and the fourth optical window 330 (and corresponding detectors positioned behind the optical windows) at an angle with respect to the first optical window 324 (and the corresponding optical emitter positioned behind the optical window) can be useful for limiting the amount of light received by the detectors, If the detectors receive too much light, the detectors may become saturated and stop providing useful analysis information.
[079] When the sensor 300 is arranged as illustrated in Figure 5, the optical emitter 350 and the optical detectors 352, 356, 358 can be centered around the optical analysis area 314 so as to emit light to and receive light from a geometric center of the optical analysis area. Such a configuration can be useful to provide a central optical inspection area where light is directed and received during operation of sensor 300. In other examples, however, one or more of optical emitter 350 and optical detectors 352, 356, 358 can be offset from the optical analysis area 314 so that light is not emitted to and/or received from a center of the optical analysis area, but rather in a region outside the center of the optical analysis area.
[080] Applicant has found that, in some examples, moving an optical emitter so that the emitter directs light adjacent to a wall of an optical analysis area rather than at a center of the optical analysis area can increase the amount of light detected, and therefore, the generated signal power of an optical detector positioned to receive light from the optical analysis area. For example, the signal strength generated by an optical detector positioned to receive light from the optical analysis area can be approximately 2 to approximately 5 times stronger than the optical emitter is displaced to direct light adjacent to a wall of an analysis area. optics rather than in a center of the optical analysis area. Increased signal strength can be useful for a variety of reasons. As an example, in applications where scale builds up on an optical detector during service, the ability to generate stronger signals can extend the length of time the optical sensor can remain in service between cleaning and maintenance.
[081] Without wishing to be bound by any particular theory, it is believed that the deviation of an optical emitter with respect to a center of an optical analysis area can reduce the amount of light that is reflected in the optical analysis area (for example , due to turbidity of the fluid sample and/or reflection off internal or external surfaces of the optical analysis area) when compared to whether the optical emitter is positioned to direct light at the center of an optical analysis area. This in turn can increase the power of the signal generated by one or more optical detectors that surround the optical analysis area.
[082] Figure 6 is a cross-sectional drawing showing an alternative configuration of the sensor 300 in which the optical emitter has been offset with respect to the center of the optical analysis area. Like components of sensor 300 in Figures 3-6 are identified by like reference numerals. For example, sensor 300 in Figure 6 is illustrated as including optical emitter 350, first optical detector 352, second optical detector 356, and third optical detector 358. Optical emitter 350 is positioned behind first optical window 324; first optical detector 352 is positioned behind second optical window 326; second optical detector 356 is positioned through third optical window 328; a third optical detector 358 positioned behind the fourth optical window 330. the windows 324, 326, 328, 330 each facing the optical analysis area 314 for directing light into and receiving light from a fluid sample present in the optical analysis area . In addition, sensor 300 in Figure 6 included optical filters 225 (Figure 2) positioned between the optical emitter/optical detectors and optical windows 324, 326, 328, 330. In other examples, sensor 300 may not include the optical filters or it may have a different number or arrangement of optical filters.
[083] In contrast to the configuration of optical sensor 300 in Figure 5, in the exemplary configuration of Figure 6, the first optical window 324 (eg, the optical emitter window) is shifted with respect to a center of the optical analysis area. 314. In particular, first optical window 324 is positioned closer to fourth optical window 330 (e.g., third optical detector window) than third optical window 328 (e.g., second optical detector window). In operation, light emitted by optical emitter 350 and traveling in a linear direction through a geometric center of the first optical window 324 may neither be directed nor intercept a geometric center of the optical analysis area 314. of optical emitter 324, light can be directed closer to a wall of optical analysis area 314 than if light were directed at a geometric center of the optical analysis area.
[084] For example, in Figure 6, the optical analysis area 314 defines a geometric center 388. The geometric center 388 can be an arithmetic mean location of all points around the perimeter limiting the optical analysis area. For example, where optical analysis area 314 is a circular tube, geometric center 388 may be a point within the circle that is equidistant from all points on the circumference of the circle. By displacing the first optical window 324 with respect to the geometric center 388, light emitted through the optical analysis window 324 with respect to the geometric center of the optical analysis area. Instead, light may converge at a location between the geometric center 388 of the optical analysis area 314 and a wall bordering the optical analysis area.
[085] In the example of Figure 6, the optical analysis area 314 is illustrated as a fluid tube (eg, glass tube, quartz tube, sapphire tube) that defines an inner diameter 390 and an outer diameter 392, where the inner diameter is separated from the outer diameter by a pipe wall thickness. Optical windows 324, 326, 328 and 330 are positioned adjacent to and, in some examples, in contact with an outer surface of the fluid tube. In addition, in Figure 6, the optical windows 324, 326, 328, and 330 are spherical lenses that have a diameter greater than the inner diameter 390 of the fluid tube. Other configurations of optical windows 324, 326, 328 and 330 and optical analysis area 314 are possible for sensor 300.
[086] The optical emitter 350 and/or the first optical window 324 can be shifted with respect to a geometric center of the optical analysis area 314 in a variety of different ways. In the example of Figure 6, optical emitter 350 and first optical window 324 are moved in the negative Y direction with respect to second optical window 326 so that light traveling linearly from a geometric center of the first optical window is directed closer. of the third optical detector 358 than of the second optical detector 356. In other examples, the optical emitter 350 and the first optical window 324 can be moved in the positive Y direction with respect to the second optical window 326 so that light traveling linearly from a geometric center of first optical window 324 is oriented closer to second optical detector 356 than third optical detector 358.
[087] In some examples, optical emitter 350 and/or first optical window 324 is positioned so that an axis 380 (Figure 5), located in a common plane of optical windows 324, 326, 328, 330 and extending across a geometric center of the first optical window 324, does not intersect an axis 382 which is located in the common plane of optical windows 324, 326, 328, 330 and which extends through a geometric center of the second optical window 326. of the first optical window 324 is offset with respect to the geometric center 388 may vary, e.g., based on the optical window size and the sensor configuration, in some examples, the geometric center of the first optical window is shifted (e.g., in the direction Positive or negative Y indicated in Figure 6) from geometric center 388 a distance ranging from approximately 0.5 millimeters to approximately 10 millimeters, such as a distance ranging from approximately 1 millimeter to approximately 3 millimeters. Positioning first optical window 324 so that light emitted by optical emitter 350 is directed adjacent to a wall of optical analysis area 314 can increase the power of signals generated by optical detectors 352, 356, 358.
[088] The power of the signals detected by the optical detectors 352, 356, 358 will vary, for example, depending on the design of the specific detectors and the configuration of the optical sensor 300. In an example where the optical sensor 300 is arranged as illustrated in Figure 6 (and where optical analysis area 314 is a quartz tube having an inner diameter of 3 mm and an outer diameter of 5 mm, and the first optical window 224 is shifted in the negative Y direction by 1 mm), it is expected that the third optical detector 358 will provide a fluorescence signal of 19.9 microWatts (μW). By contrast, if optical windows 324, 326, 328, 330 were symmetrical around optical analysis area 314 such that first optical window 224 was not shifted in the negative Y direction, third optical detector 358 is expected to provide a 10.5 µW fluorescence signal under similar conditions (eg similar fluid flowing through optical analysis area 314).
[089] Figure 7 illustrates yet another exemplary arrangement of optical sensor 300. Optical sensor 300 in Figure 7 is the same as the optical sensor of Figure 6 except that the fourth optical window 330 and the third optical window 328 have been moved in the direction X negative. In one example, where optical sensor 300 is arranged as illustrated in Figure 7 (and where optical analysis area 314 is a quartz tube having an inner diameter of 3 mm and an outer diameter of 5 mm, the first optical window 224 is shifted in the negative Y direction by 1 mm, the fourth optical window is shifted in the negative X direction by 1 mm, and the third optical detector 358 is shifted in the negative X direction by 2.5 mm), the third detector is expected to optical 358 provides a fluorescence signal of 22.2 μW when tested under similar conditions, as discussed above with respect to the example in connection with Figure 6. This is greater than when all components are symmetrical around the optical analysis area 314 and when only the first optical window 324 is shifted.
[090] The techniques described in this description can be implemented, at least in part, in hardware, software, firmware or any combination thereof. For example, various aspects of the techniques described can be implemented within one or more processors, including one or more microprocessors, digital signal processors (DSPs), application-specific integrated circuits (ASICs), programmable field gate arrays ( FPGAs), or any other integrated or discrete logic circuit, as well as any combinations of such components. The term "processor" may refer in general to any preceding logic circuit, alone or in combination with another logic circuit, or any other equivalent circuit, a control unit comprising hardware may also perform one or more of the techniques in this description.
[091] Such hardware, software, and firmware may be implemented within the same device or within separate devices to support the various operations and functions described in this description. In addition, any of the described units, modules or components can be implemented together or separately as distinct but interoperable logical devices. The representation of different features as modules or units is intended to emphasize different functional aspects, and does not necessarily imply that such modules or units must be realized by separate hardware or software components. Rather, functionality associated with one or more modules or units may be realized by separate hardware or software components, or integrated within common or separate hardware or software components.
[092] The techniques described in this description may also be incorporated or encoded in a non-transient computer-readable medium, such as a computer-readable storage medium, containing instructions. Instructions embedded or encoded in a computer-readable storage medium can make a programmable processor, or other processor, perform the method, for example, when the instructions are executed. Computer readable storage media may include forms of volatile and/or non-volatile memory including, for example, random access memory (RAM), read-only memory (ROM), programmable read-only memory (PROM), memory only. erasable programmable read-only (EPROM), electronically erasable programmable read-only memory (EEPROM), flash memory, a hard disk, a CD-ROM, a floppy disk, a cassette, a magnetic medium, optical medium or other medium readable by computer.
[093] Several examples have been described. These and other examples are within the scope of the following claims.

权利要求:
Claims (18)
[0001]
1. Optical sensor CHARACTERIZED by the fact that it comprises: an optical emitter that is configured to direct light to an optical emitter window in a fluid sample; a first optical detector that is configured to detect light emitted by the optical emitter and transmitted through the fluid sample; a second optical detector that is configured to detect light emitted by the optical emitter and diffused by the fluid sample; a third optical detector that is configured to detect fluorescent emissions emitted by the fluid sample in response to light emitted by the optical emitter; an optical emission filter positioned between the optical emitter and the fluid sample; a first optical detection filter positioned between the first optical detector and the fluid sample; a second optical detection filter positioned between the second optical detector and the fluid sample; and a third optical detection filter positioned between the third optical detector and the fluid sample, wherein the optical emission filter, the first optical detection filter, and the second optical detection filter are each configured to filter the same lengths. of light waveform such that substantially any light detected by the first optical detector and the second optical detector is light emitted from the optical emitter and passing through the fluid sample, and the optical emitter window is offset so that the geometric center of the window The optical emitter is positioned closer to the third optical detector than the second optical detector.
[0002]
2.Sensor according to claim 1, CHARACTERIZED by the fact that the third optical filter is configured to filter substantially all wavelengths of light emitted by the optical emitter and passing through the optical emission filter.
[0003]
3. Sensor according to claim 1, CHARACTERIZED by the fact that the optical emission filter, the first optical detection filter, and the second optical detection filter are each configured to filter wavelengths of light greater than approximately 300 nanometers.
[0004]
4. Sensor according to claim 1, CHARACTERIZED in that it further comprises a housing that defines an optical analysis area through which the fluid sample can travel for optical analysis, the housing including an optical emitter assembly that supports the optical emitter, a first optical emitter assembly that supports the first optical emitter, a second optical emitter assembly that supports the second optical emitter, and a third optical emitter assembly that supports the third optical emitter.
[0005]
5. Sensor according to claim 4, CHARACTERIZED by the fact that the optical emitter window is positioned between the optical emitter and the optical analysis area, and the housing further comprises a first optical detector window positioned between the first detector optical and optical analysis area, a second optical detector window positioned between the second optical detector and the optical analysis area, and a third optical detector window positioned between the third optical detector and the optical analysis area.
[0006]
6. Sensor according to claim 5, CHARACTERIZED by the fact that the first optical detector window is positioned on an opposite side of the optical analysis area from the optical emitter window, the second optical detector window is positioned at an angle of approximately 90 degrees with respect to the optical emitter window, and the third optical detector window is positioned on an opposite side of the optical analysis area from the second optical detector window.
[0007]
7. Sensor according to claim 5, CHARACTERIZED by the fact that the optical analysis area comprises a tube having an inner diameter and an outer diameter, and in which the optical emitter window, the first optical detector window, the second optical detector window, and the third optical detector window each comprise a spherical lens positioned to face the outer diameter of the tube.
[0008]
8. Sensor, according to claim 7, CHARACTERIZED by the fact that the tube defines a geometric center through which the fluid sample travels, and the optical emitter window is displaced with respect to the geometric center of the tube so that light emitted through a geometric center of the spherical lens of the optical emitter window does not pass through the geometric center of the tube.
[0009]
9. Sensor according to claim 7, CHARACTERIZED by the fact that the second optical detector window is positioned at an angle of approximately 90 degrees with respect to the optical emitter window and the third optical detector window is positioned on one side opposite of the tube of the second optical detector window.
[0010]
10.Sensor, according to claim 1, CHARACTERIZED by the fact that it further comprises a temperature sensor, a pH sensor, and a conductivity sensor.
[0011]
11.Sensor, according to claim 10, CHARACTERIZED by the fact that the electronics for the temperature sensor are positioned in a circuit panel that contains one of the first, second or third optical detectors, the electronics for the pH sensor are in a circuit board that contains a different one of the first, second, or third optical detectors, and electronics for the conductivity sensor are in a circuit board that contains a different one of the first, second, or third optical detectors.
[0012]
12. Sensor according to claim 1, CHARACTERIZED in that it comprises: a housing that defines an optical analysis area through which a fluid sample travels for optical analysis, the housing including an optical emitter assembly that supports the optical emitter, a first optical emitter assembly that supports the first optical detector, the first optical detection filter, a second optical detector assembly that supports the second optical detector, the second optical detection filter, a third optical detector assembly carrying the third optical detector, and the third optical detection filter, wherein the housing includes the optical emitter window positioned between the optical emitter and the optical analysis area, a first optical detector window positioned between the first optical detector and the optical analysis area, a second optical detector window positioned between the second optical detector and the optical analysis area, and a third optical detector window. positioned between the third optical detector and the optical analysis area, the first optical detector window is positioned on an opposite side of the optical analysis area from the optical emitter window, the second optical detector window is positioned at an angle of approximately 90 degrees with respect to the optical emitter window, and the third optical detector window is positioned on an opposite side of the optical analysis area from the second optical detector window, and the optical emitter window is offset so that the geometric center of the Optical emitter window is positioned closer to the third optical detector window than the second optical detector window.
[0013]
13. Sensor according to claim 12, CHARACTERIZED by the fact that the optical analysis area comprises a tube having an inner diameter and an outer diameter, and the optical emitter window, the first optical detection window, the second window optical sensing window, and the third optical sensing window each comprise a spherical lens positioned facing the outer diameter of the tube.
[0014]
14. Sensor, according to claim 12, CHARACTERIZED by the fact that the optical analysis area defines a geometric center through which the fluid sample moves, and the optical emitter window is displaced with respect to the geometric center of the area of optical analysis so that light emitted through a geometric center of the optical emitter window is not directed to pass through the geometric center of the optical analysis area.
[0015]
15.Method CHARACTERIZED by the fact that it comprises: emitting light in a fluid sample through an optical emitter as defined in claim 1; detecting light emitted from the optical emitter and transmitted through the fluid sample by means of a first optical detector; detecting light emitted from the second optical emitter and diffused by the fluid sample by means of a second optical detector; and detecting fluorescent emissions emitted by the fluid sample in response to light emitted by the optical emitter by means of a third optical detector, wherein detecting light by means of the first optical detector and detecting light by means of the second optical detector further comprises filtering light from so that substantially any light detected by the first optical detector and the second optical detector is light emitted from the optical emitter and passing through the fluid sample, and emitting light through the optical emitter comprises emitting light through an optical window so that the light passing through a geometric center of the optical window is directed closer to the third optical detector than the second optical detector.
[0016]
16. Method according to claim 15, CHARACTERIZED by the fact that detecting fluorescent emissions through the third optical detector further comprises filtering substantially all wavelengths of light emitted by the optical emitter and passing through the fluid sample.
[0017]
17. Method according to claim 15, CHARACTERIZED by the fact that detecting light by means of the first optical detector comprises detecting light on an opposite side of an optical analysis area from where the optical emitter is positioned, detecting light by means of the second optical detector comprises detecting light at an angle of approximately 90 degrees with respect to where the optical emitter is positioned, and detecting fluorescent emissions by means of the third optical detector comprises detecting fluorescent emissions on an opposite side of the optical analysis area from from where the second optical detector is positioned.
[0018]
18. Method according to claim 15, CHARACTERIZED by the fact that emitting light through the optical emitter comprises emitting light through the optical emitter window so that light passing through a geometric center of the optical emitter window does not is directed to a geometric center of an optical analysis area.

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同族专利:

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公开号 | 公开日

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WO2014164204A1|2014-10-09|

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CN105143857A|2015-12-09|

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US20160033407A1|2016-02-04|

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EP2972235A4|2016-11-23|

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CA2902520A1|2014-10-09|

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CN105143857B|2019-05-07|

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AU2014249545B2|2018-06-14|

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BR112015021347A2|2017-07-18|

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US9857305B2|2018-01-02|

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AU2014249545A1|2015-08-27|

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EP2972235B1|2018-08-08|

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CA2902520C|2021-07-13|

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ES2694830T3|2018-12-27|

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EP2972235A1|2016-01-20|

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US20140264077A1|2014-09-18|

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US9140648B2|2015-09-22|

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NZ710977A|2020-05-29|

引用文献:

---

公开号 | 申请日 | 公开日 | 申请人 | 专利标题

---

---

US2950391A|1957-06-26|1960-08-23|Bausch & Lomb|Fluorometer|

---

US3264474A|1963-09-09|1966-08-02|American Instr Co Inc|Phosphorimeter attachment for fluorometer|

---

US3754145A|1971-04-16|1973-08-21|Prototypes Inc|In situ fluorometer|

---

US3763374A|1972-08-22|1973-10-02|Atomic Energy Commission|Dynamic multistation photometer-fluorometer|

---

US3901656A|1972-08-24|1975-08-26|American Monitor Corp|Apparatus and method for preparing and presenting serum chemistries for analyzation|

---

DE2408646A1|1974-02-22|1975-08-28|Max Planck Gesellschaft|REACTION KINETIC MEASURING DEVICE|

---

US3903422A|1974-06-14|1975-09-02|Gte Laboratories Inc|Digital fluorometer|

---

US4031399A|1975-02-24|1977-06-21|Beckman Instruments, Inc.|Fluorometer|

---

US4008397A|1975-04-24|1977-02-15|Hoffmann-La Roche Inc.|Fluorometer flow cell|

---

US4031398A|1976-03-23|1977-06-21|Research Corporation|Video fluorometer|

---

US4117338A|1977-05-24|1978-09-26|Corning Glass Works|Automatic recording fluorometer/densitometer|

---

DE2925855A1|1978-06-30|1980-01-17|Chelsea Instr Ltd|UNDERWATER OR SUBMERSIBLE FLUORESCENCE METER AND METHOD FOR USING SUCH AN INSTRUMENT|

---

US4178512A|1978-07-21|1979-12-11|Impulsphysik Gmbh|Deepwater in-situ fluorometer|

---

US4501970A|1982-10-12|1985-02-26|Dynatech Laboratories Incorporated|Fluorometer|

---

DE3329257A1|1983-08-12|1985-02-28|Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V., 3400 Göttingen|FLUOROMETER|

---

DD225205A1|1984-05-02|1985-07-24|Zeiss Jena Veb Carl|LASERSPEKTRALFLUOROMETER|

---

FI843409A0|1984-08-29|1984-08-29|Labsystems Oy|Fluorometer.|

---

US4877965A|1985-07-01|1989-10-31|Diatron Corporation|Fluorometer|

---

USRE34782E|1985-07-01|1994-11-08|Diatron Corporation|Fluorometer|

---

US4859864A|1987-05-07|1989-08-22|Becton, Dickinson And Company|Sensor and method for detecting the presence of air bubbles in liquid|

---

JP2635126B2|1988-09-30|1997-07-30|東亜医用電子株式会社|Particle analysis apparatus and method for determining nuclear leaf index|

---

US5061076A|1989-01-31|1991-10-29|Enzo Diagnostics, Inc.|Time-resolved fluorometer|

---

US5760900A|1989-03-18|1998-06-02|Canon Kabushiki Kaisha|Method and apparatus for optically measuring specimen|

---

EP0470982B1|1989-05-01|1993-07-14|BOHNENKAMP, Wolfram|Reflection fluorimeter|

---

US5480804A|1989-06-28|1996-01-02|Kirin Beverage Corporation|Method of and apparatus for detecting microorganisms|

---

US5094531A|1990-05-07|1992-03-10|General Atomics|Spectrophotometer to fluorometer converter|

---

WO1993011422A1|1991-12-03|1993-06-10|Applied Biosystems, Inc.|Capillary flowcell for multiple wavelength detection|

---

US5323008A|1992-03-23|1994-06-21|Diatron Corporation|Fluorometer detection system|

---

PT101290B|1993-06-18|2000-10-31|Fernandes Jose Guilherme Da Cu|FLUOROMETER FOR THE MEDICATION OF THE CONCENTRATION OF EYE LOCAL FLUOROPHORES|

---

US5489977A|1993-08-11|1996-02-06|Texaco Inc.|Photomeric means for monitoring solids and fluorescent material in waste water using a falling stream water sampler|

---

US5422719A|1993-11-12|1995-06-06|Auburn International, Inc.|Multi-wave-length spectrofluorometer|

---

FI954511A0|1995-09-22|1995-09-22|Labsystems Oy|fluorometer|

---

DE19735144C2|1997-08-13|2000-02-24|Wolfram Bohnenkamp|Reflective fluorimeter|

---

US6121053A|1997-12-10|2000-09-19|Brookhaven Science Associates|Multiple protocol fluorometer and method|

---

US6830731B1|1998-01-05|2004-12-14|Biosite, Inc.|Immunoassay fluorometer|

---

US6313471B1|1998-08-18|2001-11-06|Molecular Devices Corporation|Scanning fluorometer|

---

JP2000338030A|1999-05-27|2000-12-08|Fuji Electric Co Ltd|Method and apparatus for counting blue-green algae, algae and fine particle|

---

US6563585B1|1999-11-24|2003-05-13|University Of Maryland Biotechnology Institute|Ratiometric fluorometer|

---

US6369894B1|2000-05-01|2002-04-09|Nalco Chemical Company|Modular fluorometer|

---

DE10124235B4|2001-05-18|2004-08-12|Esytec Energie- Und Systemtechnik Gmbh|Method and device for the comprehensive characterization and control of the exhaust gas and the control of engines, especially internal combustion engines, and of components of the exhaust gas aftertreatment|

---

AT410375B|2001-05-23|2003-04-25|Anthos Labtec Instr Gmbh|fluorometer|

---

WO2003002959A1|2001-06-15|2003-01-09|Mj Research, Inc.|Controller for a fluorometer|

---

US6670617B2|2001-06-28|2003-12-30|Ondeo Nalco Company|Mirror fluorometer|

---

US7416701B2|2001-09-12|2008-08-26|Ecolab Inc.|Calibrator for fluorosensor|

---

US6836332B2|2001-09-25|2004-12-28|Tennessee Scientific, Inc.|Instrument and method for testing fluid characteristics|

---

US20030062485A1|2001-09-28|2003-04-03|Fernandez Salvador M.|Compact multiwavelength phase fluorometer|

---

EP1335060B1|2002-01-31|2007-06-20|emz-Hanauer GmbH & Co. KGaA|Turbidity sensor with temperature sensor for domestic apparatus|

---

US7099012B1|2003-03-13|2006-08-29|Turner Designs, Inc.|In-line spectrometer|

---

WO2005001436A1|2003-06-26|2005-01-06|The Secretary Of State For Defence|Improvements to fluid borne particle analysers|

---

US7384988B2|2003-08-26|2008-06-10|Union College|Method and device for fabricating aerogels and aerogel monoliths obtained thereby|

---

FI20031294A0|2003-09-10|2003-09-10|Thermo Labsystems Oy|Fluorometer calibration|

---

GB0329849D0|2003-12-23|2004-01-28|Precisense As|Fluorometers|

---

GB0404982D0|2004-03-05|2004-04-07|Smart Light Devices Ireland Lt|Fluorometer|

---

JP4304120B2|2004-04-30|2009-07-29|ベイバイオサイエンス株式会社|Apparatus and method for sorting biological particles|

---

SE0401219D0|2004-05-10|2004-05-10|Biochromix Ab|Methods for detecting conformational changes or aggregation of proteins by conjugated polyelectrolytes|

---

US7186989B2|2004-06-03|2007-03-06|University Of South Florida|Low thermal mass fluorometer|

---

US7491366B2|2005-03-03|2009-02-17|Ecolab Inc.|Portable multi-channel device for optically testing a liquid sample|

---

US20060286676A1|2005-06-17|2006-12-21|Van Camp James R|Fluorometric method for monitoring a clean-in-place system|

---

JP4756948B2|2005-08-08|2011-08-24|ベイバイオサイエンス株式会社|Flow cytometer and flow cytometry method|

---

USD580285S1|2006-01-13|2008-11-11|Invitrogen Corporation|Fluorometer|

---

DE102006005574B4|2006-02-06|2010-05-20|Johann Wolfgang Goethe-Universität Frankfurt am Main|Measuring device for determining the size, size distribution and amount of particles in the nanoscopic range|

---

US7659973B2|2006-05-26|2010-02-09|Applied Materials Southeast Asia, Pte Ltd.|Wafer inspection using short-pulsed continuous broadband illumination|

---

US7550746B2|2006-06-01|2009-06-23|Ecolab Inc.|UV fluorometric sensor and method for using the same|

---

US8809392B2|2008-03-28|2014-08-19|Ecolab Usa Inc.|Sulfoperoxycarboxylic acids, their preparation and methods of use as bleaching and antimicrobial agents|

---

US8306594B2|2008-06-12|2012-11-06|Paseman Sabrina K|Transmission fluorometer|

---

CA2689966A1|2009-01-16|2010-07-16|Innovision Inc.|Apparatus and method for multi-parameter optical measurements|

---

WO2010085736A1|2009-01-23|2010-07-29|University Of Maryland Baltimore County|Chlorophyll and turbidity sensor system|

---

DE102009020252B4|2009-05-07|2012-01-12|Krohne Optosens Gmbh|Device for measuring the fluorescence of a medium|

---

JP5537347B2|2009-11-30|2014-07-02|シスメックス株式会社|Particle analyzer|

---

US8352207B2|2010-03-31|2013-01-08|Ecolab Usa Inc.|Methods for calibrating a fluorometer|

---

US8269193B2|2010-03-31|2012-09-18|Ecolab Usa Inc.|Handheld fluorometer and method of use|

---

WO2011121749A1|2010-03-31|2011-10-06|古河電気工業株式会社|Optical information analysis device and optical information analysis method|

---

JP4805417B1|2010-03-31|2011-11-02|古河電気工業株式会社|Optical information analysis apparatus and optical information analysis method|

---

US8373140B2|2010-03-31|2013-02-12|Ecolab Usa Inc.|Fluorometric sensor|

---

US8248611B2|2010-03-31|2012-08-21|Ecolab Usa Inc.|Handheld optical measuring device and method of use|CN104114449B|2012-03-27|2016-08-24|利乐拉瓦尔集团及财务有限公司|The sensor device of measurement of species concentrations|

---

US9612221B2|2014-10-14|2017-04-04|Chem-Aqua, Inc. + Pyxis Lab, Inc.|Opto-electrochemical sensing system for monitoring and controlling industrial fluids|

---

US11016031B2|2014-11-05|2021-05-25|Ballast Water Monitoring A/S|Ballast water analysis system|

---

CN111413305A|2015-03-25|2020-07-14|阿格迪有限责任公司|Modular testing device for analyzing biological samples|

---

EP3190400A1|2016-01-08|2017-07-12|Openfield|A downhole fluid properties analysis probe, tool and method|

---

US10072962B2|2016-07-05|2018-09-11|Ecolab Usa Inc.|Liquid out-of-product alarm system and method|

---

US10132752B2|2017-01-27|2018-11-20|The United States Of America, As Represented By The Secretary Of The Navy|Hand-held laser biosensor|

---

US10209176B2|2017-02-28|2019-02-19|Marqmetrix, Inc.|Fluid flow cell including a spherical lens|

---

CN107037022A|2017-04-25|2017-08-11|清华大学深圳研究生院|The biological amount detection systems of a kind of immersion optic probe and Fresh Watcr Blue Algae|

---

WO2018204425A1|2017-05-01|2018-11-08|Ionic Superior Technologies|Real-time multi-parameter monitor for metal-working systems|

---

GB2565061B|2017-07-28|2020-09-02|Adey HoldingsLtd|Optical testing of central heating system water|

---

CA3102240A1|2018-06-01|2019-12-05|Orb Xyz, Inc.|Detecting an analyte in a medium|

---

US20200190428A1|2018-12-16|2020-06-18|Ahmed Anthony Shuja|Nanofiltration automation for polishing of oil resin plant extracts|

法律状态:
2018-11-13| B06F| Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]|

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2020-03-10| B06U| Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]|

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2020-12-15| B06A| Patent application procedure suspended [chapter 6.1 patent gazette]|

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2021-07-06| B09A| Decision: intention to grant [chapter 9.1 patent gazette]|

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2021-09-08| B16A| Patent or certificate of addition of invention granted [chapter 16.1 patent gazette]|Free format text: PRAZO DE VALIDADE: 20 (VINTE) ANOS CONTADOS A PARTIR DE 06/03/2014, OBSERVADAS AS CONDICOES LEGAIS. |

优先权:

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申请号 | 申请日 | 专利标题

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US13/796,594|US9140648B2|2013-03-12|2013-03-12|Fluorometer with multiple detection channels|

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US13/796,594|2013-03-12|

---

PCT/US2014/021197|WO2014164204A1|2013-03-12|2014-03-06|Fluorometer with multiple detection channels|

---